Saturday 13 July 2013

The Science of Vaccination- an Insight from Hilleman Labs

Get to know the approach and vaccine research that Hilleman Labs, employs to provide better health care facilities to developing countries.

There is big gap between the healthcare facilities provided by the developing nations and developed nations. Vaccination programs help developing countries, defend deadliest of diseases. Hilleman Labs, a partner of Merck & Co. and Wellcome Trust, have channelized their vaccine research to help people fight and overcome fatal diseases in developing countries. Vaccine manufacturing needs research, ultra-modern techniques, and artisan. The artisans at Hilleman Labs focus on:

·         Diseases of importance to developing countries
·         Transformational technology for vaccine development and administration

The vaccines like rotavirus vaccines, human papilloma virus vaccines, TB vaccines, pneumococcal conjugate vaccines, and Hepatitis A vaccines are developed for diseases responsible for highest mortality and morbidity rates in developing countries. The vaccines are developed and delivered based on disease targets and antigens, which are calculated on epidemiologic data and disease burden. The heat stability, usability, and affordability of the vaccine are improved either by using existing technology or inventing a new one.

The vaccine research model of Hilleman Labs encapsulates the following:

·         Due-Diligence
·         Identify Vaccine Antigen
·         Identify Vaccine Technology
·         Optimization
·         Preclinical Development
·         Clinical Phase I / II
·         Technology Transfer for Manufacturing



The Project selection process:

·         Public health interest (Possible reasons why this vaccine is needed)
·         Technical probability (What is the probability of vaccine’s success)
·         Financial feasibility (Cost and investment involved in vaccine manufacture and licensing)
·         Keeping in mid National Regulatory Authority (NRA) and WHO Guidelines
·         Consulting stakeholders and peer groups

“It is estimated that globally 0.6 million children under the age of 5 die annually due to rotavirus diarrhea and another 2 million are hospitalized. 90% of these deaths occur in developing countries.” –Courtesy: Hilleman Labs.

Public health systems that can ensure fairness in global health scenario will be a reality only through easy and affordable access to life-saving immunization programs. Well equipped with transformational vaccine research technologies, we will deliver new age preventive healthcare to the developing world in the near future.

Our expertise in vaccine research is channelized towards helping people in the developing world to fight the deadliest of diseases with vaccines that are within their reach. A first-of-its-kind initiative, Hilleman Laboratories is an equal joint-venture partnership formed between Merck & Co., a global research-driven pharmaceutical company and Wellcome Trust, a global charitable foundation dedicated to human and animal health. Headquartered in India, Hilleman Laboratories is an international organization strengthened by the presence of global leadership and scientific team, which is working incessantly to develop safe, effective, affordable and sustainable vaccines for developing countries

Thermo stable Rotavirus vaccine is one of the current projects that Hilleman Labs, has been working on. The research on rotavirus vaccine, examine formulations to improve stability, usability, portability and affordability of thin strips or granules.  Making vaccination a medium to combat deadly diseases helps save lives.


Hilleman Laboratories is a vaccine manufacture  and committed to developing high impact, TB vaccines, Hepatitis A vaccines, affordable vaccines for people in developing countries in an innovative and sustainable manner.